Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828114 | 0.78 | ERCC5 (0.49) | HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL27368380 | 0.74 | SMN1; SMN2 (0.50) | HPGDHSD17B10LPAR3SMN1; SMN2ENPP2 | |
| SCHEMBL10365071 | 0.71 | HSD17B3 (0.41) | HPGD | |
| SCHEMBL6911822 | 0.69 | LMNA (0.48) | HPGDHSD17B10CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL5862791 | 0.69 | SMN1; SMN2 (0.72) | HPGDHSD17B10CYP1A2SMN1; SMN2 | |
| SCHEMBL8126959 | 0.69 | TLR8 (0.47) | HPGDHSD17B10CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL1255019 | 0.69 | LMNA (0.61) | SMN1; SMN2FAAH | |
| SCHEMBL11234921 | 0.68 | LMNA (0.49) | HPGDHSD17B10CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL11744882 | 0.68 | TP53 (0.43) | — | |
| SCHEMBL11746575 | 0.68 | TP53 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229660-B1 | NITROGEN-CONTAINING ARYL METHOXYTHIOPHENE DERIVATIVES AND ACID ADDITION SALTS THEREOF, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1990-09-26 | — | — | EP | disclosed |
| US-4778803-A | Nitrogen-arylmethoxy-thiophene derivatives and acid addition salts thereof, and pharmaceutical preparations containing these compounds | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1988-10-18 | — | — | US | disclosed |
| EP-0229660-A2 | Nitrogen-containing aryl methoxythiophene derivatives and acid addition salts thereof, process for their preparation and pharmaceutical compositions containing them | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1987-07-22 | — | — | EP | disclosed |