Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828647 | 0.81 | HTR1A (0.38) | HTR2ADRD4MAPTTP53HTR1A | |
| SCHEMBL7830765 | 0.80 | ADRA1A (0.67) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL7824411 | 0.79 | ADRA1A (0.70) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL8649198 | 0.77 | HTR2A (0.43) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL7815509 | 0.76 | HTR2A (0.61) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL8651520 | 0.75 | HTR2A (0.59) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL14048396 | 0.74 | HTR2A (0.49) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL7816876 | 0.74 | ADRA1A (0.66) | HTR2ADRD4ADRA1AHTR1ADRD2 | |
| SCHEMBL7817436 | 0.74 | HTR2A (0.56) | HTR2ADRD4ADRA1AMAPTTP53 | |
| SCHEMBL13200718 | 0.74 | ADRA1A (0.56) | HTR2ADRD4ADRA1AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732332-A1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-18 | — | — | EP | claimed |
| EP-0732332-B1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | AVENTIS PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0732332-A1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-18 | — | — | EP | disclosed |