Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828641 | 0.81 | HTR2A (0.54) | HTR1ADRD2HTR2AHTR7DRD3 | |
| SCHEMBL31240335 | 0.61 | DRD2 (0.45) | HTR1ADRD2HTR2AHTR7KCNH2 | |
| SCHEMBL7830765 | 0.60 | ADRA1A (0.67) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL9360288 | 0.60 | ACHE (0.53) | HTR1ADRD2HTR2AHTR7DRD3 | |
| SCHEMBL7824411 | 0.58 | ADRA1A (0.70) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL10527898 | 0.58 | HRH3 (0.52) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL4574733 | 0.58 | DRD2 (0.57) | HTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL9428377 | 0.57 | CCR5 (0.44) | KCNH2 | |
| SCHEMBL13809609 | 0.55 | HTR2A (0.40) | HTR1ADRD2HTR2ARAB9ADRD4 | |
| SCHEMBL8011318 | 0.54 | DRD2 (0.69) | HTR1ADRD2HTR2AKCNH2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732332-B1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | AVENTIS PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |