SCHEMBL7828963 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MAPT	P10636	2/20	0.38

▸	HDAC4	P56524	1/20	0.37

▸	MLYCD	O95822	4/20	0.36

▸	NPSR1	Q6W5P4	2/20	0.35

▸	HTT	P42858	1/20	0.35

▸	ALDH1A1	P00352	1/20	0.34

▸	TSHR	P16473	1/20	0.34

▸	GAA	P10253	1/20	0.34

▸	MCHR1	Q99705	1/20	0.33

▸	KDM5A	P29375	1/20	0.33

▸	HDAC8	Q9BY41	1/20	0.32

▸	MEN1	O00255	1/20	0.31

▸	KMT2A	Q03164	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6204567	0.87	HDAC4 (0.49)	MAPTHDAC4MLYCDALDH1A1MCHR1
SCHEMBL7556725	0.87	KMT2A (0.43)	MAPTNPSR1ALDH1A1TSHRGAA
SCHEMBL7826245	0.82	NPSR1 (0.39)	MAPTNPSR1ALDH1A1TSHRMEN1
SCHEMBL7829858	0.78	MAPT (0.48)	MAPTHTTALDH1A1TSHR
SCHEMBL7828560	0.76	GPBAR1 (0.40)	HDAC4MEN1KMT2A
SCHEMBL7750180	0.75	MEN1 (0.45)	MAPTNPSR1HTTALDH1A1TSHR
SCHEMBL7754982	0.74	KDM5A (0.52)	MAPTNPSR1ALDH1A1GAAKDM5A
SCHEMBL7826753	0.73	KDM4E (0.38)	MAPTNPSR1ALDH1A1GAAMEN1
SCHEMBL7559771	0.73	MEN1 (0.50)	MAPTNPSR1HTTALDH1A1TSHR
SCHEMBL321543	0.73	MEN1 (0.45)	MAPTNPSR1HTTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1095021-A1	QUINOLINE DERIVATIVES	Active Biotech AB (SE)	2001-05-02	—	—	EP	disclosed
WO-2000003991-A1	QUINOLINE DERIVATIVES	ACTIVE BIOTECH AB (SE)	2000-01-27	—	—	WO	disclosed