SCHEMBL7829080

SCHEMBL7829080

O=CC(Cc1ccccc1)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.61
GAA P10253 1/20 0.61
TDP1 Q9NUW8 1/20 0.60
POLB P06746 2/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.54
PKM P14618 1/20 0.54
AADAT Q8N5Z0 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
TSHR P16473 1/20 0.47
HSD11B1 P28845 1/20 0.46
HTT P42858 1/20 0.45
RECQL P46063 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
CASP3 P42574 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8075909 1.00 ALDH1A1 (0.61) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL7284629 1.00 ALDH1A1 (0.61) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL8283041 0.89 TDP1 (0.51) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL8283049 0.87 CASP3 (0.50) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL13937943 0.85 TDP1 (0.58) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL7796562 0.85 TDP1 (0.58) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL7797911 0.85 TDP1 (0.58) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL12834925 0.83 ALDH1A1 (0.65) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL28798215 0.80 TDP1 (0.47) ALDH1A1GAATDP1POLBL3MBTL1
SCHEMBL10588010 0.79 ALDH1A1 (0.61) ALDH1A1GAATDP1POLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778827-B1 PROCESS FOR PRODUCING A BETA-AMINO ALCOHOL DEGUSSA (DE) 2001-12-12 EP claimed
US-5994555-A (4S,5S)-4-BENZYL-2-OXO-OXAZOLIDINE-5-CARBOXYLIC ACID FROM PHENYLALANINE AND PHTHALIC ANHYDRIDE F. HOFFMAN-LAROCHE AG (CH) 1999-11-30 US claimed
US-5859248-A Process for the production of a β-amino alcohol F. HOFFMAN-LA ROCHE AG (CH) 1999-01-12 US claimed
EP-0778827-A1 PROCESS FOR PRODUCING A BETA-AMINO ALCOHOL F. HOFFMANN-LA ROCHE AG (CH) 1997-06-18 EP claimed
WO-1996007642-A1 PROCESS FOR PRODUCING A β-AMINO ALCOHOL F. HOFFMANN-LA ROCHE AG (DE) 1996-03-14 WO claimed
EP-0635493-A2 Process for the preparationof a beta-aminoalcohol F. HOFFMANN-LA ROCHE AG (CH) 1995-01-25 EP claimed
EP-0778827-B1 PROCESS FOR PRODUCING A BETA-AMINO ALCOHOL DEGUSSA (DE) 2001-12-12 EP disclosed
US-5994555-A (4S,5S)-4-BENZYL-2-OXO-OXAZOLIDINE-5-CARBOXYLIC ACID FROM PHENYLALANINE AND PHTHALIC ANHYDRIDE F. HOFFMAN-LAROCHE AG (CH) 1999-11-30 US disclosed
US-5919949-A α-hydroxy acid esters useful as intermediates in the production of β-amino alcohols HOFFMANN-LA ROCHE INC. (US) 1999-07-06 US disclosed
US-5859248-A Process for the production of a β-amino alcohol F. HOFFMAN-LA ROCHE AG (CH) 1999-01-12 US disclosed
EP-0738724-B1 Process for the preparation of an N-terbutylamide derivative HOFFMANN LA ROCHE (CH) 1998-11-04 EP disclosed
US-5698698-A Process for preparation of N-tert.butyl-decahydro-2- 2(R)-hydroxy-4-phenyl-3(S)-phthalimidobutyl!-(4aS,8aS)-isoquinoline-3(S)-carboxamide HOFFMANN-LA ROCHE INC. (US) 1997-12-16 US disclosed
US-5641886-A Process for preparation of N-tert.butyl-decahydro-2-[2(R)-hydroxy-4-phenyl-3(S)-phthalimidobutyl]-(4AS,8AS)-isoquinoline-3(S)-carboxamide HOFFMANN-LA ROCHE INC. (US) 1997-06-24 US disclosed
US-5502210-A 1H-isoindole-1,3-dione compounds HOFFMANN-LA ROCHE INC. (US) 1996-03-26 US disclosed
WO-1996007642-A1 PROCESS FOR PRODUCING A β-AMINO ALCOHOL F. HOFFMANN-LA ROCHE AG (DE) 1996-03-14 WO disclosed
US-5495025-A Isoindole compounds which are useful as intermediates HOFFMANN-LA ROCHE INC. (US) 1996-02-27 US disclosed
US-5455353-A 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides HOFFMANN-LA ROCHE INC. (US) 1995-10-03 US disclosed
EP-0635493-A2 Process for the preparationof a beta-aminoalcohol F. HOFFMANN-LA ROCHE AG (CH) 1995-01-25 EP disclosed
EP-0634410-A1 Process for the preparation of a N-tert.butylisoquinolin-3-carboxamide derivative and intermediate compounds of these process F. HOFFMANN-LA ROCHE AG (CH) 1995-01-18 EP disclosed
US-4973585-A INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME MERRELL DOW PHARMACEUTICALS (US) 1990-11-27 US disclosed