Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836205 | 0.89 | TUBB4A (0.44) | PDE10AHPGDPKMSMN1; SMN2TP53 | |
| SCHEMBL7831401 | 0.77 | SMN1; SMN2 (0.54) | HPGDSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL7835666 | 0.76 | ALDH1A1 (0.36) | HPGDSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7830294 | 0.74 | AMY1A (0.40) | PDE10AHPGDPKMGUSBSMN1; SMN2 | |
| SCHEMBL8491272 | 0.72 | SMN1; SMN2 (0.39) | PDE10AHPGDGUSBSMN1; SMN2NPC1 | |
| SCHEMBL8495848 | 0.71 | ALDH1A1 (0.47) | HPGDGUSBSMN1; SMN2NPC1MEN1 | |
| SCHEMBL7808062 | 0.71 | GAA (0.56) | SMN1; SMN2MEN1KMT2ADHODHTSHR | |
| SCHEMBL14917022 | 0.70 | PDE5A (0.48) | HPGDGUSBSMN1; SMN2NPC1MEN1 | |
| SCHEMBL7834113 | 0.70 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1TP53RAB9AMEN1 | |
| SCHEMBL7821021 | 0.70 | MAPK1 (0.53) | HPGDGUSBSMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567107-B1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-21 | — | — | EP | claimed |