Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998196 | 0.86 | POLB (0.61) | MAPK1NR4A3RIPK2POLBNPC1 | |
| SCHEMBL2544046 | 0.83 | MAPK1 (1.00) | MAPK1NPC1RAB9AL3MBTL1MAPT | |
| SCHEMBL17324822 | 0.81 | MAPK1 (0.69) | MAPK1NR4A3RIPK2POLBNPC1 | |
| SCHEMBL24385178 | 0.81 | RIPK2 (0.73) | MAPK1NR4A3RIPK2POLBNPC1 | |
| SCHEMBL4034195 | 0.79 | NR4A3 (0.80) | MAPK1NR4A3RIPK2POLBNPC1 | |
| SCHEMBL798337 | 0.79 | ALDH1A1 (0.73) | MAPK1NR4A3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12902785 | 0.78 | MAPT (0.78) | MAPK1NR4A3POLBMAPTSMN1; SMN2 | |
| SCHEMBL13593554 | 0.76 | ALDH1A1 (0.63) | MAPK1NR4A3POLBMAPK14MAPT | |
| SCHEMBL17582618 | 0.76 | MAPK1 (0.61) | MAPK1NR4A3RIPK2POLBNPC1 | |
| SCHEMBL76980 | 0.75 | NR4A3 (0.50) | MAPK1NR4A3RIPK2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | KIM TAE-SEONG (US) | 2012-03-22 | — | — | US | disclosed |
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110118252-A1 | SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | HGF, HGFAC, MET | MAPK1 2585/4885NR4A3 2287/4885RIPK2 4290/4885 |
| US-20110118252-A1 | SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE | HGF, HGFAC, MET | MAPK1 1915/4885NR4A3 2637/4885RIPK2 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.