Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | C5 | P01031 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094264 | 0.90 | ACVR2A (0.36) | PPIAC5 | |
| SCHEMBL3078154 | 0.86 | ACVR2A (0.35) | RARB | |
| SCHEMBL7820761 | 0.83 | LTA4H (0.41) | — | |
| SCHEMBL7819943 | 0.81 | KMT2A (0.44) | MAPK1HPGD | |
| SCHEMBL7831118 | 0.81 | RARA (0.37) | RARB | |
| SCHEMBL7832137 | 0.77 | GPR174 (0.33) | — | |
| SCHEMBL7831489 | 0.77 | NR3C2 (0.40) | HPGD | |
| SCHEMBL3071384 | 0.75 | XDH (0.38) | — | |
| SCHEMBL3093008 | 0.74 | ACVR2A (0.36) | — | |
| SCHEMBL3087282 | 0.74 | MEN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |