Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817685 | 0.94 | EDNRA (0.37) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL7828475 | 0.91 | EDNRA (0.40) | EDNRAEDNRB | |
| SCHEMBL7822983 | 0.90 | EDNRA (0.41) | EDNRAALDH1A1LMNATSHRHCRTR2 | |
| SCHEMBL7828399 | 0.90 | HCRTR2 (0.41) | EDNRAEDNRBALDH1A1TSHRHCRTR2 | |
| SCHEMBL7341811 | 0.87 | EDNRA (0.38) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL7824055 | 0.85 | POLB (0.42) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL7339606 | 0.81 | EDNRA (0.38) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL7829083 | 0.79 | POLB (0.42) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL7337701 | 0.79 | EDNRA (0.41) | EDNRAEDNRBLMNASMN1; SMN2 | |
| SCHEMBL7826340 | 0.78 | EDNRB (0.42) | EDNRAEDNRBALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |