Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824055 | 0.94 | POLB (0.42) | POLBMCHR1EDNRBEDNRAKMT2A | |
| SCHEMBL7827728 | 0.92 | EDNRB (0.42) | EDNRBEDNRAKMT2ALMNA | |
| SCHEMBL7824156 | 0.91 | ALDH1A1 (0.46) | POLBMCHR1EDNRAKMT2AALDH1A1 | |
| SCHEMBL7340189 | 0.88 | EDNRB (0.40) | POLBMCHR1EDNRBEDNRAKMT2A | |
| SCHEMBL7826340 | 0.86 | EDNRB (0.42) | EDNRBEDNRAKMT2AALDH1A1LMNA | |
| SCHEMBL7832196 | 0.86 | HSD11B1 (0.43) | POLBALDH1A1LMNA | |
| SCHEMBL7817685 | 0.85 | EDNRA (0.37) | EDNRBEDNRAKMT2AALDH1A1LMNA | |
| SCHEMBL7817130 | 0.85 | EDNRB (0.45) | MCHR1EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL7817798 | 0.82 | HSD11B1 (0.41) | EDNRBEDNRAKMT2AALDH1A1LMNA | |
| SCHEMBL7333608 | 0.81 | CHRM5 (0.42) | POLBMCHR1EDNRBEDNRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |