Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 3/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLRA3 | O75311 | 5/20 | 0.35 |
| ▸ | GLRB | P48167 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817685 | 0.90 | EDNRA (0.37) | HCRTR2EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL7831316 | 0.90 | EDNRA (0.37) | HCRTR2EDNRAEDNRBALDH1A1TSHR | |
| SCHEMBL7822983 | 0.89 | EDNRA (0.41) | HCRTR2EDNRAKMT2AGLRA3GLRB | |
| SCHEMBL7336270 | 0.87 | HCRTR2 (0.41) | HCRTR2EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL7828475 | 0.84 | EDNRA (0.40) | EDNRAEDNRBKMT2AMEN1 | |
| SCHEMBL7817130 | 0.80 | EDNRB (0.45) | HCRTR2EDNRAEDNRBALDH1A1L3MBTL1 | |
| SCHEMBL7338551 | 0.80 | ALDH1A1 (0.39) | HCRTR2EDNRAKMT2AALDH1A1TSHR | |
| SCHEMBL7341811 | 0.76 | EDNRA (0.38) | HCRTR2EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL7339606 | 0.76 | EDNRA (0.38) | HCRTR2EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL7343148 | 0.76 | HSD11B1 (0.44) | HCRTR2EDNRAKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |