Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831316 | 0.91 | EDNRA (0.37) | EDNRAEDNRB | |
| SCHEMBL7337701 | 0.88 | EDNRA (0.41) | EDNRAEDNRBNPC1RAB9AGAA | |
| SCHEMBL7826340 | 0.87 | EDNRB (0.42) | EDNRAEDNRBNPC1RAB9AMEN1 | |
| SCHEMBL7822983 | 0.86 | EDNRA (0.41) | EDNRANPC1RAB9AGAAMEN1 | |
| SCHEMBL7817685 | 0.85 | EDNRA (0.37) | EDNRAEDNRBNPC1RAB9AKMT2A | |
| SCHEMBL7828399 | 0.84 | HCRTR2 (0.41) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL7338776 | 0.82 | EDNRA (0.41) | EDNRAEDNRBNPC1RAB9AGAA | |
| SCHEMBL7827728 | 0.81 | EDNRB (0.42) | EDNRAEDNRBNPC1RAB9AGAA | |
| SCHEMBL7828479 | 0.80 | PDK2 (0.32) | EDNRA | |
| SCHEMBL7341811 | 0.79 | EDNRA (0.38) | EDNRAEDNRBNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |