SCHEMBL7831373

SCHEMBL7831373

COC(=O)N(c1ccccc1)c1ccc(-n2ccc3ccccc32)c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 3/20 0.36
PTGDR Q13258 2/20 0.36
HSP90AA1 P07900 2/20 0.35
HTR2C P28335 1/20 0.35
NR3C2 P08235 1/20 0.35
TRAP1 Q12931 2/20 0.34
HSP90AB1 P08238 1/20 0.34
HSP90B1 P14625 1/20 0.34
MCL1 Q07820 1/20 0.34
CHRM4 P08173 2/20 0.34
CHRM3 P20309 2/20 0.34
PTPN1 P18031 2/20 0.34
POLB P06746 1/20 0.33
ATM Q13315 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MGLL Q99685 1/20 0.33
CHRM5 P08912 1/20 0.33
CHRM1 P11229 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7841586 0.78 CYP19A1 (0.43) PTGIRPTGDRATMTDP1L3MBTL1
SCHEMBL27532800 0.77 PTGIR (0.39) PTGIRPTGDRCHRM4CHRM3ATM
SCHEMBL27406959 0.76 ACLY (0.43) PTGIRPTGDR
SCHEMBL27407404 0.76 PTGIR (0.36) PTGIRPTGDRCHRM4CHRM3ATM
SCHEMBL7844204 0.71 CYP1A2 (0.44) PTGIRPTGDRPOLB
SCHEMBL7843554 0.70 P2RX7 (0.37) PTGIRPTGDRCHRM4CHRM3POLB
SCHEMBL3276086 0.70 L3MBTL1 (0.61) CHRM4CHRM3POLBATMTDP1
SCHEMBL2092944 0.70 PTGIR (0.52) PTGIRPTGDRATMTDP1L3MBTL1
SCHEMBL5716071 0.69 BIRC5 (0.42) HSP90AA1TRAP1HSP90AB1HSP90B1
SCHEMBL16797155 0.69 NOD2 (0.45) TRAP1PTPN1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1075073-C Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials UPJOHN CO (US) 2001-11-21 CN disclosed
EP-0807112-B1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 2001-09-05 EP disclosed
US-6124334-A A BACTERICIDE TREATING INFECTIONS CAUSED BY GRAM-POSITIVE AEROBIC BACTERIA SUCH AS STAPHYLOCOCCUS, STREPTOCOCCUS AND ENTEROCOCCUS AS WELL AS ANAEROBIC ORGANISMS SUCH AS BACTEROIDES AND CLOSTRIDIUM AND MYCOBACTERIDIUM PHARMACIA & UPJOHN COMPANY (US) 2000-09-26 US disclosed
US-5910504-A BACTERICIDES TREATING INFECTIONS PHARMACIA & UPJOHN (US) 1999-06-08 US disclosed
CN-1172484-A Phenyl oxazolidinone antibacterial agents substituted with heteroaromatic rings UPJOHN CO (US) 1998-02-04 CN disclosed
EP-0807112-A1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1997-11-19 EP disclosed
WO-1996023788-A1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS PHARMACIA + UPJOHN COMPANY (US) 1996-08-08 WO disclosed