Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855181 | 0.78 | ATM (0.48) | PPARGPPARAATML3MBTL1NPC1 | |
| SCHEMBL7831379 | 0.72 | ATM (0.47) | PPARGPPARAATML3MBTL1SMN1; SMN2 | |
| SCHEMBL7820917 | 0.71 | L3MBTL1 (0.45) | PPARGPPARAATML3MBTL1NPC1 | |
| SCHEMBL21961155 | 0.70 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4908158 | 0.70 | TSHR (0.72) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9644043 | 0.69 | ALDH1A1 (0.67) | L3MBTL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27388644 | 0.68 | TSHR (0.53) | PPARGPPARAATML3MBTL1ALDH1A1 | |
| SCHEMBL7820392 | 0.68 | L3MBTL1 (0.45) | PPARGPPARAL3MBTL1NPC1RAB9A | |
| SCHEMBL8188813 | 0.68 | CYP2C9 (0.47) | PPARGPPARA | |
| SCHEMBL8390339 | 0.68 | CYP2C9 (0.47) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460488-B1 | Sulfur-containing heterocyclic compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| US-5158943-A | Osteoporosis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-27 | — | — | US | disclosed |
| EP-0460488-A1 | Sulfur-containing heterocyclic compounds | Takeda Chemical Industries, Ltd. (JP) | 1991-12-11 | — | — | EP | disclosed |