Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820073 | 0.86 | HDAC6 (0.36) | HDAC6SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL7832157 | 0.86 | HDAC6 (0.39) | HDAC6SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL7848182 | 0.79 | GRM5 (0.37) | ALDH1A1 | |
| SCHEMBL8017785 | 0.78 | HDAC6 (0.35) | HDAC6SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL7812723 | 0.78 | TDP1 (0.35) | TDP1 | |
| SCHEMBL7830747 | 0.77 | HDAC6 (0.43) | HDAC6SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL7844105 | 0.76 | P2RX7 (0.34) | — | |
| SCHEMBL7835755 | 0.73 | ALDH1A1 (0.36) | SMN1; SMN2THRBALDH1A1LMNAHTT | |
| SCHEMBL7829183 | 0.71 | HDAC6 (0.48) | HDAC6SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL8316817 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |