Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831411 | 0.86 | HDAC6 (0.39) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8017785 | 0.85 | HDAC6 (0.35) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7832157 | 0.79 | HDAC6 (0.39) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7830747 | 0.71 | HDAC6 (0.43) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7835755 | 0.67 | ALDH1A1 (0.36) | SMN1; SMN2THRB | |
| SCHEMBL7829183 | 0.66 | HDAC6 (0.48) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7844105 | 0.65 | P2RX7 (0.34) | — | |
| SCHEMBL7812723 | 0.65 | TDP1 (0.35) | — | |
| SCHEMBL8337950 | 0.64 | GAA (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8098049 | 0.64 | SMN1; SMN2 (0.35) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |