Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820073 | 0.85 | HDAC6 (0.36) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7831411 | 0.78 | HDAC6 (0.39) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7832157 | 0.76 | HDAC6 (0.39) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7830747 | 0.73 | HDAC6 (0.43) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8524137 | 0.71 | — | — | |
| SCHEMBL7829183 | 0.65 | HDAC6 (0.48) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8563039 | 0.59 | HDAC6 (0.54) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7835755 | 0.59 | ALDH1A1 (0.36) | SMN1; SMN2 | |
| SCHEMBL4409125 | 0.58 | RAB9A (0.59) | HDAC6CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8098049 | 0.58 | SMN1; SMN2 (0.35) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100264-A | 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them | RHONE-POULENC RORER, S.A. (FR) | 2000-08-08 | — | — | US | disclosed |
| US-5990108-A | USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR | RHONE POULENC RORER S.A. (FR) | 1999-11-23 | — | — | US | disclosed |