Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670110 | 0.82 | — | — | |
| SCHEMBL7832283 | 0.76 | SMN1; SMN2 (0.49) | MEN1KMT2A | |
| SCHEMBL7398369 | 0.70 | GRIN2B (0.35) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL9204131 | 0.68 | CTSL (0.36) | MEN1KMT2A | |
| SCHEMBL7403343 | 0.68 | CTSL (0.36) | — | |
| SCHEMBL7448545 | 0.66 | SMN1; SMN2 (0.53) | MEN1KMT2A | |
| SCHEMBL7834635 | 0.66 | HTT (0.32) | LMNAMAPTDRD2 | |
| SCHEMBL7831268 | 0.65 | HTR6 (0.42) | MAPT | |
| SCHEMBL9796122 | 0.63 | ALDH1A1 (0.38) | — | |
| SCHEMBL13815640 | 0.63 | CCR1 (0.31) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |