Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354176 | 0.82 | L3MBTL1 (0.43) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL9796122 | 0.81 | ALDH1A1 (0.38) | SMN1; SMN2NPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL7747533 | 0.80 | ITGB3 (0.46) | SMN1; SMN2NPC1CYP2C19POLBALDH1A1 | |
| SCHEMBL8899910 | 0.80 | GAA (0.36) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL9204131 | 0.79 | CTSL (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL27569281 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL7398369 | 0.76 | GRIN2B (0.35) | L3MBTL1ALDH1A1GAAHTTMEN1 | |
| SCHEMBL8549480 | 0.76 | BCHE (0.35) | SMN1; SMN2NPC1CYP2C19MEN1KMT2A | |
| SCHEMBL7403343 | 0.74 | CTSL (0.36) | L3MBTL1ALDH1A1 | |
| SCHEMBL9084422 | 0.74 | CASP1 (0.36) | ALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966460-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035956-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (US) | 1998-08-20 | — | — | WO | disclosed |