Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 14/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 14/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 14/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 14/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821084 | 0.86 | PDK1 (0.61) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7833541 | 0.80 | LCK (0.68) | PDK1PDK2PDK3PDK4CYP1A2 | |
| SCHEMBL7832380 | 0.80 | ABCC9 (0.67) | PDK1PDK2PDK3PDK4CYP1A2 | |
| SCHEMBL7829630 | 0.77 | PDK1 (0.59) | PDK1PDK2PDK3PDK4CYP1A2 | |
| SCHEMBL7832614 | 0.77 | PDK1 (0.59) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL27823260 | 0.76 | CYP1A2 (0.60) | CYP1A2 | |
| SCHEMBL6347970 | 0.76 | PDK1 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7931365 | 0.73 | CYP1A2 (0.61) | CYP1A2 | |
| SCHEMBL7821425 | 0.72 | ABCC9 (0.53) | PDK1PDK2PDK3PDK4CYP1A2 | |
| SCHEMBL6348593 | 0.72 | PDK1 (0.67) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-5726325-A | FOR TREATING URINARY INCONTINENCE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |