Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702032 | 0.84 | TSHR (0.55) | ADRA1DADRA1AADRA1BTSHR | |
| SCHEMBL4467734 | 0.80 | TSHR (0.43) | SMN1; SMN2TSHR | |
| SCHEMBL14592881 | 0.76 | DAO (0.41) | ADRA1DADRA1AADRA1BSMN1; SMN2TSHR | |
| SCHEMBL7835947 | 0.76 | ALDH1A1 (0.38) | SMN1; SMN2 | |
| SCHEMBL4771370 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2TSHR | |
| SCHEMBL8768828 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2 | |
| SCHEMBL6243233 | 0.74 | KMT2A (0.55) | SMN1; SMN2TSHR | |
| SCHEMBL4770759 | 0.73 | KMT2A (0.55) | SMN1; SMN2TSHR | |
| SCHEMBL11507992 | 0.72 | LMNA (0.46) | SMN1; SMN2TSHR | |
| SCHEMBL13883143 | 0.72 | SIRT1 (0.40) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |