Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978569 | 0.86 | MEN1 (0.46) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL6502022 | 0.81 | MEN1 (0.41) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL7836213 | 0.80 | TP53 (0.46) | MEN1KMT2AMAPTPKMPOLB | |
| SCHEMBL6491118 | 0.80 | POLB (0.44) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL5007556 | 0.79 | HSPA9 (0.39) | MEN1KMT2AMAPTTP53LMNA | |
| SCHEMBL7825844 | 0.79 | PARK7 (0.47) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL7836004 | 0.79 | LMNA (0.46) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL7836673 | 0.79 | KMT2A (0.49) | MEN1KMT2AMAPTPKMTP53 | |
| SCHEMBL7833333 | 0.77 | TDP1 (0.46) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL31559833 | 0.75 | TP53 (0.52) | MEN1KMT2AMAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780388-B1 | 5HT1Dalpha and 5HT2A ligands | LILLY CO ELI (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5773448-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-30 | — | — | US | disclosed |
| CN-1157822-A | Pharmaceutical compounds | LILLY INDUSTRIES LTD (GB) | 1997-08-27 | — | — | CN | disclosed |
| EP-0780388-A1 | 5HT1Dalpha and 5HT2A ligands | LILLY INDUSTRIES LIMITED (GB) | 1997-06-25 | — | — | EP | disclosed |