Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7834025 | 0.99 | ADRB2 (0.47) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL7834488 | 0.94 | ADRA1A (0.50) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| Hydrochloric Acid SCHEMBL7834422 | 0.93 | ADRA1A (0.49) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL7830329 | 0.93 | HTR1A (0.56) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| Hydrochloric Acid SCHEMBL7821236 | 0.92 | HTR1A (0.55) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| Hydrochloric Acid SCHEMBL7834259 | 0.87 | ADRA1D (0.48) | HTR1AHTR7MAPK1ADRA1DADRA1A | |
| SCHEMBL7834491 | 0.85 | HTR1A (0.56) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| Hydrochloric Acid SCHEMBL7830066 | 0.85 | ADRA1D (0.50) | ADRB2ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL7833871 | 0.85 | ADRA1A (0.65) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7834012 | 0.84 | HTR1A (0.55) | ADRB2ADRA2AADRA2BADRA2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |