Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468622 | 0.91 | AKR1C3 (0.64) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL31254103 | 0.85 | KMT2A (0.87) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL28342284 | 0.85 | KMT2A (0.87) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL515302 | 0.85 | LMNA (0.61) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL30059246 | 0.85 | LMNA (0.61) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL28218708 | 0.85 | LMNA (0.61) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL28090002 | 0.83 | NFE2L2 (0.59) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL30612688 | 0.83 | NFE2L2 (0.59) | KMT2AMEN1MAPTHTTMAPK1 | |
| Nitrogen SCHEMBL8501917 | 0.82 | NFE2L2 (0.58) | KMT2AMEN1MAPTHTTMAPK1 | |
| Methylamine SCHEMBL11814441 | 0.82 | NFE2L2 (0.58) | KMT2AMEN1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946556-A4 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | LILLY CO ELI (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0946556-A1 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027093-A1 | COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |