Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551062 | 0.87 | MCL1 (0.57) | MCL1DAOALDH1A1TSHRKDM4E | |
| SCHEMBL27896993 | 0.83 | SLC9A1 (0.39) | MCL1MEN1NPC1GAARAB9A | |
| SCHEMBL10379817 | 0.79 | DAO (0.59) | MCL1DAOALDH1A1TSHRKDM4E | |
| SCHEMBL9120939 | 0.77 | CCR2 (0.51) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL29781083 | 0.76 | NR1H2 (0.55) | MCL1DAOALDH1A1TSHRNR1H2 | |
| SCHEMBL7902953 | 0.76 | NR1H2 (0.55) | MCL1DAOALDH1A1TSHRNR1H2 | |
| SCHEMBL25195634 | 0.75 | MCL1 (0.53) | MCL1DAOALDH1A1TSHRKDM4E | |
| SCHEMBL5728166 | 0.73 | MCL1 (0.50) | MCL1DAOALDH1A1TSHRKDM4E | |
| SCHEMBL3958982 | 0.73 | CCR2 (0.56) | MCL1DAOALDH1A1TSHRKDM4E | |
| SCHEMBL4098402 | 0.73 | CTSS (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918752-A4 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RES INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0918752-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1997044000-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1997-11-27 | — | — | WO | disclosed |