Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833932 | 0.90 | AKR1C3 (0.44) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL31563092 | 0.87 | AKR1C3 (0.59) | AKR1C3AKR1C2MAPTAKR1C4AKR1C1 | |
| SCHEMBL848085 | 0.87 | AKR1C3 (0.60) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL1958267 | 0.84 | MAPT (0.67) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL14575409 | 0.83 | AKR1C3 (0.47) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL847502 | 0.81 | GRIK1 (0.54) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL846947 | 0.80 | AKR1C3 (0.47) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL30567365 | 0.80 | MEN1 (0.56) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL7844252 | 0.80 | MEN1 (0.56) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL30567367 | 0.79 | MAPT (0.68) | AKR1C3AKR1C2MAPTAKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |