Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196470 | 0.86 | SMAD3 (0.57) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6514580 | 0.85 | MMP13 (0.53) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL5897605 | 0.85 | SMAD3 (0.50) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL5896618 | 0.82 | SMAD3 (0.53) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6512022 | 0.82 | MMP13 (0.55) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL1334212 | 0.80 | PIN1 (0.47) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL8197851 | 0.80 | SMAD3 (0.60) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL7470448 | 0.80 | SMAD3 (0.60) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL5680634 | 0.79 | ITGB3 (0.52) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL16418066 | 0.79 | TNKS (0.53) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1165303-C | DNA-binding indole derivatives, prodrugs and immunoconjugates thereof as antitumor agents | 全景研究有限公司 | 2004-09-08 | — | — | CN | disclosed |
| EP-0918752-A4 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RES INC (US) | 2001-11-21 | — | — | EP | disclosed |
| CN-1219841-A | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents | PANORAMA RES INC (US) | 1999-06-16 | — | — | CN | disclosed |
| EP-0918752-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5843937-A | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents | PANORAMA RESEARCH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| WO-1997044000-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1997-11-27 | — | — | WO | disclosed |