Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | F7 | P08709 | 1/20 | 0.58 |
| ▸ | F3 | P13726 | 1/20 | 0.58 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470448 | 0.90 | SMAD3 (0.60) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6179007 | 0.88 | SMAD3 (0.51) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6176518 | 0.88 | F7 (0.54) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL8196470 | 0.87 | SMAD3 (0.57) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL10466650 | 0.87 | SMAD3 (0.57) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL3027767 | 0.87 | MMP13 (0.67) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL8204182 | 0.84 | NHERF1 (0.60) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL15653618 | 0.83 | PIN1 (0.63) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL10466165 | 0.83 | MAOA (0.71) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL3644632 | 0.83 | PIN1 (0.55) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359454-B1 | CC-1065 analogs having two CPI subunits | UPJOHN CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5541339-A | ANTITUMOR AGENTS | THE UPJOHN COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1990002746-A1 | NOVEL CC-1065 ANALOGS HAVING TWO CPI SUBUNITS | THE UPJOHN COMPANY (US) | 1990-03-22 | — | — | WO | disclosed |
| EP-0359454-A1 | Novel CC-1065 analogs having two CPI subunits | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |