Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375350 | 0.77 | BCHE (0.44) | KDM4EALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL7834808 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1ALOX15CASP1CASP7 | |
| SCHEMBL6110995 | 0.69 | ALDH1A1 (0.41) | KDM4EALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL13214309 | 0.67 | XIAP (0.50) | KDM4EALDH1A1ALOX15CASP1CASP7 | |
| SCHEMBL876227 | 0.66 | PTPRC (0.49) | KDM4EALDH1A1ALOX15CASP1CASP7 | |
| SCHEMBL4444431 | 0.66 | CA1 (0.70) | SMN1; SMN2HTTCA12CA1CA2 | |
| SCHEMBL10537396 | 0.66 | CA1 (0.70) | SMN1; SMN2HTTCA12CA1CA2 | |
| SCHEMBL27570035 | 0.66 | SMN1; SMN2 (0.48) | KDM4EALDH1A1ALOX15CASP1CASP7 | |
| SCHEMBL3350901 | 0.66 | XIAP (0.47) | KDM4EALDH1A1ALOX15CASP1CASP7 | |
| SCHEMBL16259100 | 0.66 | CA12 (0.59) | KDM4EALDH1A1HTTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114033-A1 | 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | Pfizer Products Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017166-A1 | 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-03-30 | — | — | WO | disclosed |