SCHEMBL876227

SCHEMBL876227

COC(=O)c1ccc2c(c1)C=CC2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 1/20 0.49
TRPA1 O75762 3/20 0.48
CA12 O43570 3/20 0.47
CA9 Q16790 3/20 0.47
CA1 P00915 3/20 0.47
CA2 P00918 3/20 0.47
CA7 P43166 2/20 0.47
CA14 Q9ULX7 2/20 0.47
XDH P47989 1/20 0.47
MAPT P10636 4/20 0.44
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 2/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
ATM Q13315 1/20 0.44
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27902605 0.98 PTPRC (0.48) PTPRCTRPA1CA12CA9CA1
SCHEMBL8766396 0.87 CA1 (0.47) PTPRCTRPA1CA12CA9CA1
SCHEMBL353767 0.84 PTPRC (0.47) PTPRCTRPA1CA12CA9CA1
SCHEMBL1478300 0.83 TRPA1 (0.33) PTPRCTRPA1ALDH1A1
SCHEMBL28757905 0.83 CA12 (0.51) TRPA1CA12CA9CA1CA2
SCHEMBL11887310 0.83 GABRA1 (0.41) PTPRCTRPA1CA12CA9CA1
SCHEMBL23100767 0.81 RAB9A (0.52) MAPTALDH1A1KDM4EHPGDLMNA
SCHEMBL22599553 0.81 KMT2A (0.44) TRPA1MAPTALDH1A1KDM4EHPGD
SCHEMBL23529899 0.80 PTPRC (0.60) PTPRCTRPA1CA12CA9CA1
SCHEMBL484995 0.79 ALDH1A1 (0.48) CA12CA9CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907389-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-08-16 CN disclosed
EP-2619178-A1 SUBSTITUTED BENZAMIDE COMPOUNDS Grünenthal GmbH (DE) 2013-07-31 EP disclosed
CN-103097354-A Substituted benzamide compounds GRUENENTHAL CHEMIE 2013-05-08 CN disclosed
WO-2012038081-A1 SUBSTITUTED BENZAMIDE COMPOUNDS Grünenthal GmbH (DE) 2012-03-29 WO disclosed
EP-0505972-B1 Process for producing styrenic copolymer IDEMITSU KOSAN CO (JP) 1997-06-11 EP disclosed
EP-0505972-A2 Process for producing styrenic copolymer IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-09-30 EP disclosed