Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 10/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830196 | 0.89 | PDE10A (0.40) | LOXL2PDE10AKDM4ENPC1ALDH1A1 | |
| SCHEMBL7835023 | 0.88 | LOXL2 (0.49) | LOXL2PDE10AKCNN3PRKAB2PRKAG1 | |
| SCHEMBL7831998 | 0.87 | LOXL2 (0.46) | P2RX7LOXL2PDE10AMAPTKCNN3 | |
| SCHEMBL7830320 | 0.85 | S1PR4 (0.36) | P2RX7LOXL2PDE10ANPC1MAPT | |
| SCHEMBL7830500 | 0.85 | KDM5A (0.39) | P2RX7PDE10AKDM4ENPC1ALDH1A1 | |
| SCHEMBL7834918 | 0.82 | LOXL2 (0.38) | LOXL2PDE10AKCNN3CRHR1KCNN1 | |
| SCHEMBL7832607 | 0.81 | KCNN3 (0.40) | LOXL2PDE10AALDH1A1MAPTKCNN3 | |
| SCHEMBL7829913 | 0.79 | PDE10A (0.53) | P2RX7PDE10AKCNN3CRHR1PRKAB2 | |
| SCHEMBL7833197 | 0.79 | LOXL2 (0.40) | LOXL2PDE10AKDM4ENPC1ALDH1A1 | |
| SCHEMBL7832213 | 0.78 | LOXL2 (0.38) | LOXL2PDE10AKCNN3CRHR1KCNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |