Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832607 | 0.88 | KCNN3 (0.40) | PDE10AL3MBTL1KCNN3MAPTNPSR1 | |
| SCHEMBL7834870 | 0.85 | P2RX7 (0.39) | PDE10AP2RX7KCNN3MAPTLOXL2 | |
| SCHEMBL7831474 | 0.84 | PDE10A (0.35) | S1PR4PDE10ASLC6A2SLC6A4GAA | |
| SCHEMBL7831998 | 0.82 | LOXL2 (0.46) | PDE10AP2RX7KCNN3MAPTLOXL2 | |
| SCHEMBL7832891 | 0.81 | POLB (0.35) | S1PR4PDE10ASLC6A2SLC6A4MRGPRX4 | |
| SCHEMBL7830500 | 0.80 | KDM5A (0.39) | PDE10AP2RX7SLC6A4GAATP53 | |
| SCHEMBL7831740 | 0.79 | S1PR4 (0.36) | S1PR4PDE10ASLC6A2SLC6A4MRGPRX4 | |
| SCHEMBL7831183 | 0.79 | S1PR4 (0.35) | S1PR4PDE10ASLC6A2SLC6A4HPGD | |
| SCHEMBL7835023 | 0.78 | LOXL2 (0.49) | PDE10AKCNN3LOXL2TSHR | |
| SCHEMBL7830196 | 0.77 | PDE10A (0.40) | PDE10AKCNN3MAPTLOXL2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |