Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835280 | 0.92 | CBFB (0.50) | F9CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL7821635 | 0.84 | POLB (0.46) | F9CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7834248 | 0.82 | F9 (0.46) | F9CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7822768 | 0.82 | IDH1 (0.48) | F9CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7834258 | 0.80 | SMN1; SMN2 (0.50) | F9CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL7822347 | 0.80 | ALDH1A1 (0.50) | F9CYP3A4CYP2D6CYP19A1CYP11B1 | |
| Hydrochloric Acid SCHEMBL7834145 | 0.79 | SMN1; SMN2 (0.49) | F9CYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL7407358 | 0.77 | CBFB (0.50) | F9CYP19A1CYP11B1CYP11B2CBFB | |
| SCHEMBL8143473 | 0.77 | ADRB1 (0.49) | F9CYP3A4CYP2D6CYP19A1CYP11B1 | |
| SCHEMBL7821641 | 0.76 | CBFB (0.53) | F9CYP3A4CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6040327-A | INHIBITORS OF INTERLEUKINS; TREATING RHEUMATOID ARTHRITIS OR ARTHROSIS | ADIR ET COMPAGNIE (FR) | 2000-03-21 | — | — | US | disclosed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |