Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832891 | 0.88 | POLB (0.35) | LOXL2HTTALDH1A1FFAR1PDE10A | |
| SCHEMBL7832654 | 0.86 | LOXL2 (0.39) | LOXL2KCNN3HTTALDH1A1CYP1A2 | |
| SCHEMBL7831627 | 0.84 | LOXL2 (0.50) | LOXL2KCNN3KCNN1KCNN2PDE10A | |
| SCHEMBL7833855 | 0.83 | LOXL2 (0.39) | LOXL2KCNN3KCNN1KCNN2FFAR1 | |
| SCHEMBL7833197 | 0.82 | LOXL2 (0.40) | LOXL2KCNN3ALDH1A1NPSR1PDE10A | |
| SCHEMBL7832607 | 0.80 | KCNN3 (0.40) | LOXL2KCNN3ALDH1A1NPSR1KCNN1 | |
| SCHEMBL7833160 | 0.79 | PDE10A (0.41) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7835469 | 0.78 | HTR2C (0.38) | LOXL2KCNN3HTTALDH1A1KCNN1 | |
| SCHEMBL7832635 | 0.77 | GABRA1 (0.36) | LOXL2CYP1A2PDE10APRKAB2PRKAG1 | |
| SCHEMBL7832013 | 0.76 | KDM5A (0.39) | HTTPDE10APRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |