Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835597 | 0.81 | ALDH1A1 (0.49) | ERN1MAPTTRIM24TRIM33PIM1 | |
| SCHEMBL4932467 | 0.81 | LTA4H (0.59) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24379469 | 0.79 | MAPT (0.49) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7097452 | 0.79 | ERN1 (0.50) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4294807 | 0.76 | CCNB2 (0.55) | ERN1MAPTL3MBTL1CCNB2CDK1 | |
| SCHEMBL7823652 | 0.76 | CTSV (0.56) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL187798 | 0.76 | CTSV (0.56) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20663933 | 0.76 | ERN1 (0.47) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24379166 | 0.76 | CCNB2 (0.48) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3543787 | 0.76 | ERN1 (0.47) | ERN1MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |