Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834309 | 0.81 | AHR (0.51) | AHRKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL9395996 | 0.81 | AHR (0.50) | AHRALDH1A1HSD17B10 | |
| SCHEMBL1536184 | 0.81 | AHR (0.50) | AHRKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7835119 | 0.80 | MAPT (0.42) | AHRKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7834282 | 0.78 | AHR (0.41) | AHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7836341 | 0.77 | MAOA (0.53) | KMT2AMAPTMEN1ALDH1A1RAB9A | |
| SCHEMBL14199367 | 0.77 | AHR (0.43) | AHRKMT2AMAPTMEN1KIF11 | |
| SCHEMBL7493848 | 0.77 | AHR (0.52) | AHRKMT2AMAPTMEN1KIF11 | |
| SCHEMBL29951745 | 0.77 | AHR (0.59) | AHRKMT2AMAPTMEN1KIF11 | |
| SCHEMBL9274962 | 0.77 | AHR (0.59) | AHRKMT2AMAPTMEN1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012510-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |