Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | HTR6 | P50406 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | APEX1 | P27695 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | UQCRB | P14927 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CCR9 | P51686 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838659 | 0.88 | ALDH1A1 (0.55) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL7836254 | 0.84 | HTR6 (0.76) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL7824884 | 0.83 | HTR6 (0.74) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL7824099 | 0.83 | HTR6 (0.74) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL678897 | 0.83 | HTR6 (1.00) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL7837566 | 0.82 | HTR6 (0.74) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL8054947 | 0.82 | MAPT (1.00) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL8058995 | 0.80 | L3MBTL1 (0.52) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL4639504 | 0.78 | HTR6 (0.67) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 | |
| SCHEMBL7824814 | 0.77 | HTR6 (0.59) | ALDH1A1HTR6MAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815861-B1 | Sulphonamides and their use | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998665-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0815861-A1 | Sulphonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-07 | — | — | EP | disclosed |