Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCR9 | P51686 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | UQCRB | P14927 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832815 | 0.84 | L3MBTL1 (0.74) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL8056250 | 0.83 | L3MBTL1 (0.72) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7836431 | 0.80 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTHTR6 | |
| SCHEMBL7826353 | 0.77 | HTR6 (0.78) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7834367 | 0.77 | HTR6 (0.78) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7837794 | 0.75 | HTR6 (0.72) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7838659 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAMAPTHTR6 | |
| SCHEMBL7825724 | 0.74 | L3MBTL1 (0.68) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7839439 | 0.74 | L3MBTL1 (0.66) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL19399664 | 0.74 | GAA (0.68) | ALDH1A1KDM4ELMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |