Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838172 | 0.83 | FFAR1 (0.50) | ALDH1A1MAPK1LMNAHDAC3HDAC1 | |
| SCHEMBL7846693 | 0.75 | LIMK1 (0.33) | ALDH1A1MAPTMAPK1MCL1LMNA | |
| SCHEMBL7837233 | 0.72 | MEN1 (0.35) | ALDH1A1MAPTMAPK1LMNAGFER | |
| SCHEMBL25754608 | 0.71 | ALDH1A1 (0.56) | ALDH1A1TDP1MAPTMAPK1MCL1 | |
| SCHEMBL6014530 | 0.70 | HTR6 (0.49) | ALDH1A1MAPTLMNARAB9AKDM4E | |
| SCHEMBL12284487 | 0.70 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNACA9RAB9A | |
| SCHEMBL12169312 | 0.69 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNACA9HPGD | |
| SCHEMBL11859735 | 0.69 | CYP2C9 (0.72) | ALDH1A1TDP1LMNAFLT1FLT4 | |
| SCHEMBL12509428 | 0.68 | UCHL1 (0.51) | ALDH1A1MAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL19563499 | 0.68 | CA1 (0.49) | ALDH1A1MAPK1F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |