Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxindole SCHEMBL1144643 | 0.76 | AHR (1.00) | AHRPDK2NPC1MAPK13MAPK12 | |
| SCHEMBL926937 | 0.76 | HTR5A (0.35) | PDK2CASP3RAB9ASENP8SENP7 | |
| SCHEMBL29639106 | 0.76 | HTR5A (0.35) | PDK2CASP3RAB9ASENP8SENP7 | |
| Oxindole SCHEMBL29358826 | 0.76 | AHR (1.00) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL19504 | 0.76 | AHR (1.00) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL15636313 | 0.75 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL5502064 | 0.75 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL4720301 | 0.75 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL5624006 | 0.75 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL1462135 | 0.75 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780388-B1 | 5HT1Dalpha and 5HT2A ligands | LILLY CO ELI (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5773448-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-30 | — | — | US | disclosed |
| EP-0780388-A1 | 5HT1Dalpha and 5HT2A ligands | LILLY INDUSTRIES LIMITED (GB) | 1997-06-25 | — | — | EP | disclosed |