Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392918 | 0.86 | NOD2 (0.64) | MTNR1AMTNR1BKMT2ANOD2NOD1 | |
| SCHEMBL7880746 | 0.86 | MTNR1A (0.62) | MTNR1AMTNR1BKMT2ANOD2NOD1 | |
| SCHEMBL30585515 | 0.86 | NOD2 (0.64) | MTNR1AMTNR1BKMT2ANOD2NOD1 | |
| SCHEMBL7425163 | 0.86 | MTNR1A (0.58) | MTNR1AMTNR1BKMT2ANOD2NOD1 | |
| SCHEMBL24170706 | 0.84 | CCR2 (0.47) | MTNR1AMTNR1BKMT2ANOD2NOD1 | |
| SCHEMBL5622129 | 0.84 | MAPT (0.46) | MTNR1AMTNR1BMAPT | |
| SCHEMBL5622754 | 0.83 | MTNR1A (0.61) | MTNR1AMTNR1BKDM4ESMN1; SMN2CCR2 | |
| SCHEMBL29262518 | 0.83 | F10 (0.44) | MTNR1AMTNR1BKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL19252931 | 0.83 | PTGS2 (0.45) | MTNR1AMTNR1BKMT2AMAPT | |
| SCHEMBL5917423 | 0.83 | PTGS2 (0.46) | MTNR1AMTNR1BKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147110-A1 | PYRAZINO(AZA)INDOLE DERIVATIVES | VERNALIS RESEARCH LIMITED (GB) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044753-A1 | PIRAZINO(AZA)INDOLE DERIVATIVES | VERNALIS RESEARCH LIMITED (GB) | 2000-08-03 | — | — | WO | disclosed |