Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 5/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28254810 | 0.86 | NCF1 (0.45) | PDE3BPDE3ANCF1GPBAR1CYSLTR1 | |
| SCHEMBL7835368 | 0.81 | NCF1 (0.59) | PDE3BPDE3ANCF1NQO1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28426316 | 0.80 | NCF1 (0.57) | PDE3BPDE3ANCF1NQO1ALDH1A1 | |
| SCHEMBL18487520 | 0.78 | CYP1A2 (0.53) | PDE3BPDE3ANCF1CBFBABL1 | |
| SCHEMBL31716032 | 0.77 | PDE3B (0.48) | PDE3BPDE3ANCF1CBFBABL1 | |
| SCHEMBL17430137 | 0.77 | NCF1 (0.49) | PDE3BPDE3ANCF1CBFBABL1 | |
| SCHEMBL22325682 | 0.76 | ALDH1A1 (0.54) | PDE3BPDE3AABL1ALDH1A1 | |
| SCHEMBL29629324 | 0.76 | ALDH1A1 (0.54) | PDE3BPDE3AABL1ALDH1A1 | |
| SCHEMBL9458374 | 0.76 | MAPT (0.43) | PDE3BPDE3AF2RL3ALDH1A1TP53 | |
| SCHEMBL7835292 | 0.75 | MAPT (0.56) | NCF1GPBAR1CYSLTR1PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | claimed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | claimed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | claimed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | claimed |
| EP-0470795-B2 | Process for the manufacture of nitriles | AVECIA LTD (GB) | 2001-02-21 | — | — | EP | disclosed |
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0470795-B1 | Process for the manufacture of nitriles | ZENECA LTD (GB) | 1995-01-25 | — | — | EP | disclosed |
| EP-0470794-B1 | Process for the preparation of nitriles | ZENECA LTD (GB) | 1995-01-25 | — | — | EP | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| EP-0495948-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1992-07-29 | — | — | EP | disclosed |
| CN-1059516-A | The preparation method of biphenylcarbonitriles | ICI LTD (GB) | 1992-03-18 | — | — | CN | disclosed |
| CN-1058965-A | The method for preparing new quinoline | ICI PLC (GB) | 1992-02-26 | — | — | CN | disclosed |
| WO-1992002508-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-20 | — | — | WO | disclosed |
| EP-0470795-A1 | Process for the manufacture of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| EP-0470794-A1 | Process for the preparation of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |