Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17430137 | 0.81 | NCF1 (0.49) | PDE3BPDE3ANCF1MAPTMEN1 | |
| SCHEMBL31716032 | 0.81 | PDE3B (0.48) | PDE3BPDE3ANCF1KMT2ANQO1 | |
| SCHEMBL22325682 | 0.80 | ALDH1A1 (0.54) | CYP1A2KDM4EPOLBPDE3BPDE3A | |
| SCHEMBL29629324 | 0.80 | ALDH1A1 (0.54) | CYP1A2KDM4EPOLBPDE3BPDE3A | |
| SCHEMBL806266 | 0.79 | NCF1 (0.65) | CYP1A2KDM4ELMNAPOLBCASP6 | |
| SCHEMBL30081476 | 0.79 | NCF1 (0.65) | CYP1A2KDM4ELMNAPOLBCASP6 | |
| SCHEMBL8643145 | 0.79 | CYP1A2 (0.50) | CYP1A2KDM4ELMNAPOLBCASP6 | |
| SCHEMBL424926 | 0.79 | PDE3B (0.52) | CYP1A2KDM4ELMNAPOLBCASP6 | |
| SCHEMBL21273257 | 0.78 | NQO1 (0.69) | KDM4EPDE3BPDE3ANCF1NQO1 | |
| SCHEMBL7837270 | 0.78 | PDE3B (0.49) | PDE3BPDE3ANCF1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10300155-B2 | Alpha-synuclein ligands | WASHINGTON UNIVERSITY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170189566-A1 | ALPHA-SYNUCLEIN LIGANDS | WASHINGTON UNIVERSITY (US) | 2017-07-06 | — | — | US | disclosed |
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | CYP1A2 571/4885KDM4E 1199/4885LMNA 981/4885 |
| US-10300155-B2 | Alpha-synuclein ligands | SNCA, PARK7, LRRK2 | CYP1A2 4628/4885KDM4E 4649/4885LMNA 3391/4885 |
| US-20170189566-A1 | ALPHA-SYNUCLEIN LIGANDS | SNCA, PARK7, LRRK2 | CYP1A2 4628/4885KDM4E 4649/4885LMNA 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.