Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.70 |
| ▸ | HTR1A | P08908 | 9/20 | 0.70 |
| ▸ | MPO | P05164 | 10/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847502 | 0.87 | SLC6A4 (0.67) | SLC6A4HTR1AMPOHTR7KCNH2 | |
| SCHEMBL7844899 | 0.82 | HTR1A (1.00) | SLC6A4HTR1AMPO | |
| SCHEMBL7837922 | 0.78 | HTR1A (1.00) | SLC6A4HTR1AMPO | |
| SCHEMBL5238410 | 0.75 | MPO (1.00) | SLC6A4MPO | |
| SCHEMBL6971576 | 0.72 | MPO (0.92) | SLC6A4MPO | |
| SCHEMBL7836873 | 0.72 | HTR1A (1.00) | SLC6A4HTR1AMPO | |
| SCHEMBL2404556 | 0.71 | MPO (0.71) | SLC6A4HTR1AMPO | |
| SCHEMBL2404396 | 0.70 | MPO (1.00) | SLC6A4HTR1AMPO | |
| SCHEMBL7833926 | 0.70 | HTR1A (1.00) | SLC6A4HTR1AHTR7 | |
| SCHEMBL7836788 | 0.69 | HTR1A (1.00) | SLC6A4HTR1AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | claimed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |