Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848793 | 0.94 | MMP1 (0.35) | MMP1MMP13MMP3APPDGAT1 | |
| SCHEMBL7946535 | 0.93 | MMP1 (0.37) | MMP1MMP13L3MBTL1MMP3APP | |
| SCHEMBL7856205 | 0.91 | ALDH1A1 (0.38) | MMP1MMP13ALDH1A1LMNAAPP | |
| SCHEMBL7955660 | 0.90 | XIAP (0.35) | MMP1MMP13ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6221034 | 0.86 | MMP1 (0.38) | MMP1MMP13MMP3APPFKBP1A | |
| SCHEMBL7837114 | 0.86 | ADAM17 (0.37) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL7837117 | 0.86 | ADAM17 (0.37) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL7960600 | 0.84 | MMP1 (0.37) | MMP1MMP13MMP3APPMMP2 | |
| SCHEMBL7955118 | 0.84 | MMP1 (0.37) | MMP1MMP13MMP3APPFKBP1A | |
| SCHEMBL7842288 | 0.83 | MMP1 (0.37) | MMP1MMP13MMP3APPMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |