Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837542 | 0.91 | MMP1 (0.36) | ALDH1A1MMP1FKBP1AAPPKMT2A | |
| SCHEMBL7848793 | 0.89 | MMP1 (0.35) | MMP1MMP9FKBP1AAPPMMP13 | |
| SCHEMBL7955660 | 0.88 | XIAP (0.35) | ALDH1A1MMP1MMP13LMNA | |
| SCHEMBL7946535 | 0.86 | MMP1 (0.37) | MMP1MMP9APPKMT2AMMP13 | |
| SCHEMBL7946538 | 0.84 | MMP1 (0.41) | ALDH1A1MMP1MMP9APPKMT2A | |
| SCHEMBL7946539 | 0.84 | MMP1 (0.41) | ALDH1A1MMP1MMP9APPKMT2A | |
| SCHEMBL7955756 | 0.82 | ALDH1A1 (0.36) | ALDH1A1MMP1MMP9FKBP1AKMT2A | |
| SCHEMBL7955753 | 0.82 | ALDH1A1 (0.36) | ALDH1A1MMP1MMP9FKBP1AKMT2A | |
| SCHEMBL6221034 | 0.81 | MMP1 (0.38) | MMP1MMP9FKBP1AAPPMMP13 | |
| SCHEMBL7960600 | 0.80 | MMP1 (0.37) | MMP1MMP9APPMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |