Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838436 | 1.00 | TSHR (0.41) | TSHRALDH1A1HTTLMNAPOLB | |
| SCHEMBL7836808 | 0.86 | LMNA (0.42) | TSHRALDH1A1HTTLMNAPOLB | |
| SCHEMBL7836803 | 0.86 | LMNA (0.42) | TSHRALDH1A1HTTLMNAPOLB | |
| SCHEMBL7837924 | 0.75 | CYP11B1 (0.59) | ALDH1A1POLBHSP90AA1 | |
| SCHEMBL7837929 | 0.75 | CYP11B1 (0.59) | ALDH1A1POLBHSP90AA1 | |
| SCHEMBL10762081 | 0.75 | ALDH1A1 (0.59) | TSHRALDH1A1HTTHDAC1HDAC6 | |
| SCHEMBL7835223 | 0.73 | ARG1 (0.40) | TSHRALDH1A1HTTMEN1KMT2A | |
| SCHEMBL7835227 | 0.73 | ARG1 (0.40) | TSHRALDH1A1HTTMEN1KMT2A | |
| SCHEMBL6761465 | 0.72 | ALDH1A1 (0.52) | TSHRALDH1A1HTTLMNAHDAC1 | |
| SCHEMBL7830204 | 0.70 | ATM (0.39) | TSHRALDH1A1HTTHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500864-B1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LTD (GB) | 2001-09-19 | — | — | EP | disclosed |
| US-5292749-A | Quinuclidine derivatives; bronchodilator agents, treatment of respiratory system disorders | PFIZER INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0500864-A1 | ANTIMUSCARINIC BRONCHODILATORS | Pfizer Limited (GB) | 1992-09-02 | — | — | EP | disclosed |
| WO-1992004346-A1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LIMITED (GB) | 1992-03-19 | — | — | WO | disclosed |