Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831749 | 0.90 | GPR119 (0.47) | GPR119KDM1AMEN1KMT2ATACR1 | |
| SCHEMBL8441644 | 0.85 | GPR119 (0.49) | GPR119KDM1AMEN1KMT2ATACR1 | |
| SCHEMBL7839284 | 0.82 | GPR119 (0.46) | GPR119KDM1AMEN1KMT2ATACR1 | |
| SCHEMBL2952664 | 0.77 | OPRD1 (0.47) | GPR119MEN1KMT2ATACR1JAK2 | |
| SCHEMBL7831085 | 0.76 | ALDH1A1 (0.50) | GPR119KDM1AMEN1KMT2ATACR1 | |
| SCHEMBL7831565 | 0.76 | GPR119 (0.54) | GPR119MEN1KMT2ATACR1USP30 | |
| SCHEMBL21626597 | 0.75 | GPR119 (0.62) | GPR119MEN1KMT2AMAPT | |
| SCHEMBL25212948 | 0.75 | USP2 (0.47) | GPR119TACR1TSHRALOX15ATM | |
| SCHEMBL15804314 | 0.73 | GPR119 (0.50) | GPR119MEN1KMT2ATACR1TSHR | |
| SCHEMBL7175345 | 0.72 | GPR119 (0.48) | GPR119TACR1USP30TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |