Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.55 |
| ▸ | HTR1D | P28221 | 9/20 | 0.55 |
| ▸ | HTR1B | P28222 | 9/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308076 | 0.83 | KMT2A (0.53) | HTR1AHTR1DHTR1BNPBWR1MCHR1 | |
| SCHEMBL7850568 | 0.83 | FAAH (0.46) | FAAHNPC1 | |
| SCHEMBL6306090 | 0.82 | HTR1A (0.58) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL6313105 | 0.79 | HTR1A (0.70) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL7951589 | 0.74 | KMT2A (0.51) | HTR1ANPC1NPBWR1MCHR1MAPT | |
| SCHEMBL6307506 | 0.74 | HTR1A (0.61) | HTR1AHTR1DHTR1BKDM4EALDH1A1 | |
| SCHEMBL8567402 | 0.74 | HTR1A (0.50) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL7943338 | 0.73 | RXFP1 (0.59) | NPC1NPBWR1MCHR1KDM4EALDH1A1 | |
| SCHEMBL7591765 | 0.73 | NPC1 (0.48) | HTR1ANPC1NPBWR1MCHR1KDM4E | |
| SCHEMBL7586158 | 0.73 | NPC1 (0.46) | HTR1ANPC1NPBWR1MCHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689536-B1 | NAPHTHALENE DERIVATIVES | PFIZER (US) | 2001-05-23 | — | — | EP | claimed |
| EP-0701819-B1 | Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist | PFIZER (US) | 2000-08-16 | — | — | EP | claimed |