Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818412 | 0.86 | CA1 (0.44) | BRS3SAE1UBA2HRH3TYMP | |
| SCHEMBL25911828 | 0.81 | MMP13 (0.55) | BRS3MMP13MMP1MMP2MMP9 | |
| SCHEMBL7842828 | 0.81 | BRS3 (0.54) | BRS3SAE1UBA2HRH3MMP13 | |
| Hydrochloric Acid SCHEMBL8368581 | 0.79 | BRS3 (0.52) | BRS3SAE1UBA2HRH3MMP13 | |
| SCHEMBL1507946 | 0.77 | HRH3 (0.47) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL8305559 | 0.77 | BRS3 (0.50) | BRS3SAE1UBA2HRH3MMP13 | |
| SCHEMBL7129739 | 0.77 | BRS3 (0.52) | BRS3SAE1UBA2HRH3TYMP | |
| SCHEMBL6688212 | 0.77 | TYMP (0.45) | BRS3SAE1UBA2HRH3TYMP | |
| SCHEMBL7843395 | 0.75 | HRH3 (0.47) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7468183 | 0.74 | BRS3 (0.47) | BRS3SAE1UBA2HRH3TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |